What Is a Dog Vaccine DA2PPv?

Dr. Joe Alcorn, M.S., D.V.M.

Dr. Joe Alcorn is founder of Care Animal Hospital in Temecula, California. He has a Bachelor of Science in Biology and Doctor of Veterinary Medicine from Colorado State University. He is a member of the American Veterinary Medical Association and his advice has been featured in large publications like Bustle and Martha Steward.

Home » Blog » What Is a Dog Vaccine DA2PPv?

Pet owners find ways to keep dogs healthy and happy. You may commonly see the DA2PPv vaccine as you research a dog’s core vaccinations. We’re going to explain what a DA2PPv dog vaccine is, when your pet should get it, and the diseases it can protect your dog from.

What Is a Dog Vaccine DA2PPv?

DA2PPv is a multivalent and core vaccine that helps dogs build immunity against the distemper virus, adenovirus types 1 and 2, parainfluenza, and parvovirus. It’s among the core vaccines that protect dogs, especially puppies, from fatal diseases. Dogs usually must get it as early as six to eight weeks of age.

Knowing what the DA2PPv dog vaccine is can help secure your pet’s health plan, mainly since it protects dogs from highly contagious and life-threatening diseases. It’s important that you understand the benefits of DA2PPV so you’ll feel at peace in securing this vaccine for your dog.

Veterinarian hugging a brown dog

How Does the DA2PPv Dog Vaccine Work?

The DA2PPv vaccine exposes a dog’s body to a small amount of inactivated or weakened pathogens. As a result, a dog’s immune system safely recognizes and responds to pathogens. Consequently, its body will fight the actual infection should it contract the viruses. 

The American Animal Hospital Association’s 2022 Canine Vaccination Guidelines recommend the DA2PPv vaccination for every dog except those with medical reasons.

What Diseases Does the DA2PPv Combat?

The DA2PPv is a core vaccine that dogs need annually. The letters in the abbreviation stand for each kind of virus that dogs can catch.


The first letter in the DA2PPv vaccine stands for distemper. This deadly canine disease causes pneumonia and neurological dysfunction. It’s common among puppies and young dogs with no vaccination history.

Airborne droplets from sneezing, eye secretions, and direct contact with infected feces can carry the virus. Symptoms of canine distemper include fever, poor appetite, vomiting, weight loss, fatigue, seizures, diarrhea, and upper respiratory problems.

Our clinic can provide antibiotics to prevent secondary infections, IV fluids to combat dehydration, and anticonvulsants as a solution for seizures. Unfortunately, there’s no antiviral drug that can fight the distemper virus. Thus, getting the DA22Pv vaccine is the first line of defense.

Adenovirus Types 1 and 2

The next letter represents adenovirus types 1 and 2. This virus causes the viral kennel cough. It leads to upper respiratory illnesses such as bronchitis and bronchiolitis

Similar to distemper, puppies and unvaccinated dogs are at the most risk of adenovirus. Dogs can get this viral infection through contact with the mucous membrane. 

Brown daschund puppy standing on a vet table

The common symptoms are fever, appetite loss, vomiting, diarrhea, abdominal pain, lethargy, swollen lymph nodes, and an enlarged liver. While no specific cure for adenovirus exists, dogs may recover through emergency care and services.


The first P in DA2PPv represents parainfluenza. The vaccine protects dogs against this highly contagious virus. Parainfluenza is another viral strain that can cause fever, appetite loss, runny nose, dry cough, and lethargy.

It’s a common infection among dogs who frequent close spaces like pet shops, kennels, pounds, and boarding places. Contact with infected items and mucous membrane secretions can pass the virus.

Most dogs will recover from urgent care and medications, although vaccinating your dog can prevent this.


The next P represents parvovirus, a notorious infectious disease among dogs. Puppies under four months old and unvaccinated dogs are the most susceptible to parvo.

Dogs can get the parvovirus through direct contact with an infected dog, fecal matter, shared items, and a virus that lingers in the environment for at least a month. This virus attacks a dog’s intestinal system, causing fever, vomiting, appetite loss, bloody stool, abdominal pain, severe dehydration, and lethargy.

There’s also no exact cure for this virus, although hospitalization is often the best way to treat it. It can be costly, which is why it’s essential to have pet insurance.

How Often Do Dogs Need the DA2PPv Vaccine?

DA2PPv is one of the crucial vaccines for dogs, particularly puppies. This is why it’s important that your pet starts the immunization series as early as six weeks of age.

Vet wearing gloves vaccinating a dog while its laid out on the table
  • Puppies under 16 weeks old: As a puppy develops its immune system, it’s more at risk for catching infectious illnesses. Thus, it’s best to vaccinate puppies as early as six to eight weeks of age. Follow up with booster shots every two to four weeks until four months old.
  • Unvaccinated dogs aged 16 weeks old: If the dog has no vaccine history, vaccinate as soon as possible. Follow up with a one-time booster within 14 to 28 days. Consider getting a booster shot after one to three years.
  • Adult dogs: Vaccinate 12 months after the initial series. Continue with booster shots every one to three years, depending on local laws or your vet’s recommendation.

Regardless of age, your pet should avoid places and situations with a high risk of infection until 14 days after the final DA2PPv booster shot. For instance, dog parks or homes with unvaccinated dogs. After the last dose, it would be okay for your pet to start socializing.

Related Questions

How Much Does DA2PPv Cost?

The cost of DA2PPv varies, although the general range is between $24 to $50. This is still cheaper than hospitalization bills if your pet contracts any viruses that the DA2PPv vaccine can combat.

What Are the Potential Risks and Side Effects of DA2PPv?

Vaccine reactions such as small lumps at the injection site may occur within 10 to 15 minutes after getting a DA2PPv shot. In case you observe vomiting, facial swelling, and breathing problems when you arrive home, return to our clinic right away for treatment.

Can Dog Owners Decline the DA2PPv Vaccine?

Owners may decline the DA2PPv vaccine because this isn’t mandatory in the United States, in contrast to the rabies vaccine. However, doing so puts your dog at risk of contracting viral infections or spreading diseases.


DA2PPv is a core vaccine that protects dogs against the distemper virus, adenovirus types 1 and 2, parainfluenza, and parvovirus. Dogs should have this vaccine around six to eight weeks of age, along with booster shots every one to three years. Aside from immunization, schedule examinations to prevent diseases and guarantee optimum health.